الانتشار البكتيري وأنماط مقاومة المضادات الحيوية لإصابات المسالك البولية لدى بعض النساء بمدينة ترهونة ، ليبيا
DOI:
https://doi.org/10.35778/rjt54k71Keywords:
Urinary Tract Infection, Escherichia coli, Antimicrobial Resistance, Tarhuna, LibyaAbstract
Urinary Tract Infections (UTIs) are a prevalent clinical challenge among women worldwide: This study aimed to estimate the prevalence of UTIs in Tarhuna, Libya, identify the predominant bacterial uropathogens, and evaluate their antimicrobial susceptibility patterns, addressing the local gap in updated epidemiological data
Methods: A retrospective cross-sectional study was conducted by analyzing 250 laboratory records from Tarhuna city between March 2023 and February 2024. Significant bacteriuria was defined as a colony count of 10^5 CFU/ml. To ensure data integrity, duplicate records for the same patient were excluded. Antimicrobial susceptibility testing was performed and interpreted in accordance with the Clinical and Laboratory Standards Institute (CLSI) guidelines
Results: The overall prevalence of UTIs was 58% (n=145/250; 95% CI: 51.8% – 64.2%). Escherichia coli was the most frequent isolate (54%), followed by Staphylococcus spp. (14%), Klebsiella spp. (11%), Proteus spp. (10%), Pseudomonas spp. (6%), and Streptococcus spp. (5%). E. coli exhibited alarmingly high resistance to Amoxicillin (96.1%) and Ampicillin (100%). Conversely, Nitrofurantoin demonstrated a high sensitivity rate of 73%. The age group of 25–35 years was the most affected, accounting for 38% of cases
Conclusion: The study reveals a high prevalence of UTIs and a concerning rise in antibiotic resistance against conventional treatments in Tarhuna. These findings emphasize the urgent need for antibiotic stewardship and the reliance on culture-based sensitivity results rather than empirical therapy. Nitrofurantoin remains a highly effective option for the management of UTIs in the region
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